9 Ways to Boost glutathione for Lupus

Why Glutathione?

Our body is under stress at all timed from a variety of metabolic and environmental toxins.  When the body is under such stress, our body tends to accelerate oxidation in our bodies, which in turn releases toxins in our bodies potentially causing damage and inflammation.

This is why we need plenty of “antioxidants” to neutralize the toxins in our bodies to protect the integrity and function of our cells.

For Lupus and various autoimmune conditions, we have more free radicals which can be very damaging by not only worsening our condition but also perpetuating it.  

Imagine a burning home, it produces so many harmful gases like carbon dioxide.  In order to neutralize it would behoove one to wear a mask to reduce inhalation of such gas, right?

Same is true for free radicals produced by oxidative stress.  As Autoimmune patients, you can assume we are constantly under oxidative stress from all the antibodies that are being produced.  The body is left to clear the debris and fragmented DNA and in the process, it tends to produce lots of free radicals.

This is precisely why we advocate the Elimination Diet.

We need to reduce all potential inflammatory foods that add to the fire in our body and provide it with ample amount of nutrient rich foods that have lots of antioxidants to protect the integrity and functions of our cells.

THE MASTER ANTI-OXIDANT:

Glutathione (GSH) is a protein molecule that provides the greatest antioxidant protection which also recharges other antioxidants within the body.  (1)

Every cell in the body produces glutathione and many scientists believe that the level of glutathione in our cells is a strong indicator of how long we will live. 

Glutathione, for this reason, has been coined with the term “master anti-oxidant”.  Consider Glutathione as the cell’s security guard protecting the genetic equipment from outside attack. It is estimated that each cell in the body withstands 10,000 hits by free radicals each day. Glutathione disarms these free radicals before they wreak havoc and cleans up the oxidative stress related damage that has occurred.

Our cells in the body withstand an estimated 10,000 hits by free radicals each day. But Glutathione to our rescue comes and is able to disarm these free radicals before they wreak havoc in our body and clean up the heal the damage that it causes.

Do you see why we Lupies need this powerful antioxidant?

Glutathione also plays a significant role in immune function. Studies have shown that glutathione strengthens T cells which are critical for modulating the immune system.   They are the cells that coordinate the attack against pathogenic bacteria, viruses, etc. hopefully while keeping our other cells safe.  

As we know that’s not the case for us.  Our T cells are over stimulated and can easily become overactive which can trigger allergies and auto-immune disease flares and responses.

Glutathione Decreases with age

Levels of glutathione decline with aging as the majority of individuals in our society become more toxic and deficient.  To add to this, our environmental toxicity is higher than ever before.  And due to the prevalence in the leaky gut in Autoimmune and Lupus patients, this is a significant problem.  

Researchers estimate that the average person loses glutathione at 8-12% per decade (2).  Increased health challenges from infection, poor diet,  toxic air, medication usage, etc. can deplete these stores at a much faster rate. 

Scientists estimate that a 30% reduction of glutathione is enough for cellular dysfunction to occur.  Remember, Lupus patients already have cellular dysfunction.  

Studies have shown that optimal vitamin D is necessary for optimal glutathione production (3).  And the majority of Lupus and Autoimmune patients are extremely deficient in vitamin D (4).  Optimal vitamin D levels should be between 60-100 ng/ml so please check it and work to get it up.

Your doctor may tell you that you’re normal at 30 ng/ml but that’s still not optimal so I strongly advise you to get your levels of Vitamin D levels up higher.

9 Foods to Boost Glutathione for Lupus.

Glutathione is produced from amino acids (proteins) in our bodies, mainly glycine, glutamic acid, and cysteine.  Such amino acids should naturally be consumed through our diet.

The best vegetable sources include avocados, onions, spinach, & asparagus.  Various supplements such as curcumin, resveratrol, and quercetin have also been shown to boost glutathione content.

Unfortunately, vegetable sources are still very low in these critical amino acids.

The best food sources are through high-quality, grass-fed beef, and organic animal products.  These include non-denatured grass-fed beef, and cultured, raw grass-fed dairy products and raw, organic eggs.

Lupus Glutathione Boosting WaysLupus Glutathione Boosting WaysLupus Glutathione Boosting Ways

References:

1. Nuttall S, Martin U, Sinclair A, Kendall M. 1998. Glutathione: in sickness and in healthThe Lancet; 351(9103):645-646

2.Richie JP Jr, Leutzinger Y, Parthasarathy S, Malloy V, Orentreich N, Zimmerman JA. Methionine restriction increases blood glutathione and longevity in F344 rats. FASEB J. 1994 Dec;8(15):1302-7. PMID:8001743

3. Jain SK, Micinski D. Vitamin D upregulates glutamate cysteine ligase and glutathione reductase, and GSH formation, and decreases ROS and MCP-1 and IL-8 secretion in high-glucose exposed U937 monocytes. Biochem Biophys Res Commun. 2013 Jul 19;437(1):7-11. PMID: 23770363

4. Holick MF, Chen TC. Vitamin D deficiency: a worldwide problem with health consequences. Am J Clin Nutr. 2008 Apr;87(4):1080S-6S. PMID: 18400738

 

 

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