Low Dose Naltrexone for Autoimmunity: What Are The Benefits?

by | Aug 22, 2018 | Lupus Blog | 0 comments

Most of you know I am a rebel when it comes to just about everything in my life.  I’m used to experimenting with various holistic options to improve my life with Lupus.

Most recently, I’ve been experimenting with low dose naltrexone (LDN). I waited to share this information with you to make sure I could notice the clinical differences it made in regards to my health.

I’ve read the research and I felt the risks were minimal, as compared to other options for Lupus. I felt compelled to try it and see how I feel on it.

You do need a prescription for it, so I asked my Rheumatologist and he politely declined and advised me against it.

However, I asked a physician friend to prescribe it for me and the effects were positive.

Benefits of Low Dose Naltrexone

I’ve been experimenting with LDN for the last three months and I have to say, I’ve experienced the following benefits:

  • Improved focus
  • Decreased muscle pain
  • Improved sleep
  • Improved mood

Naltrexone was originally used for opiate and alcohol addiction in large doses between 50-100 mg.

In contrast, low dose naltrexone (1.0-4.5 mg/d) can be effectively used for autoimmune conditions, with very low side effects.

How Does Low Dose Naltrexone Help With Autoimmunity?

It increases endorphins and allows for interaction with certain receptors in the body, which in turn helps to regulate our cells to grow and improve immunity.

LDN suppresses certain immune responses in order to bring our immune system back into balance, ultimately decreasing autoimmunity. (1)

Also, it is effective for pain reduction because it blocks our brain’s pain signals. (2)

LDN reduces inflammation in the body by blocking certain immune responses.

Additionally, low dose naltrexone:

  • Decreases T-cell activity
  • Provides an anti-inflammatory effect
  • Improves gut health
  • Improves response to infection, especially viral infections
  • Positively effects mood and quality of life

There is so much valid research on LDN and its benefits on autoimmunity and the following conditions:

  • Crohn’s disease
  • Ulcerative colitis
  • Inflammatory bowl disease and irritable bowel syndrome
  • Sarcoidosis
  • Psoriasis
  • Psoriatic arthritis
  • Multiple sclerosis
  • Hashimoto’s
  • Graves disease
  • Ankylosing spondylitis
  • Juvenile idiopathic arthritis
  • Polymyositis
  • Scleroderma
  • Sjogren’s syndrome

What are the Side Effects of Low Dose Naltrexone?

Side effects of LDN are minimal and rarely occur. These side effects may include:

  • Insomnia
  • Headache
  • Diarrhea
  • Anxiety
  • Drowsiness
  • Vivid dreams (4)

What’s the Dose for Low Dose Naltrexone?

Typical dose is 1.5-4.5 mg.  It’s ideal to start with 1-2 mg and then increase until the effects are noticed, but do not exceed more than 4.5

I am on 3 mg and I feel great.

If you want to know more about how LDN can be an option for you, visit ldnresearchtrust.org.

And for those of you who want to give LDN a try, ask your doctor. You can also contact me at [email protected]

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See you next time.


Zhao. Int Immunopharmacol.2016.Li. Cancer Biol There. 2015
Li. Med Hyptheses 2012;79:754-6.
Hutchinson et al. Brain Behav Immun 2010;24:83-95
Ploesser J, Weinstock LB, Thomas E. Internat J Pharm Compound 2010

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